Protein Details: Gap junction alpha-4 protein

Protein ID

ICDB_Pro_0492

Protein Name

Gap junction alpha-4 protein

Gene Name

GJA4

Organism

Homo sapiens (Human)

Length

333 amino acids

AlphaFoldDB

AF-P35212-F1-model_v4.pdb

Function

Sequence

MGDWGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPGCTNVCYDQAFPISHIRYWVLQFLFVSTPTLVYLGHVIYLSRREERLRQKEGELRALPAKDPQVERALAAVERQMAKISVAEDGRLRIRGALMGTYVASVLCKSVLEAGFLYGQWRLYGWTMEPVFVCQRAPCPYLVDCFVSRPTEKTIFIIFMLVVGLISLVLNLLELVHLLCRCLSRGMRARQGQDAPPTQGTSSDPYTDQVFFYLPVGQGPSSPPCPTYNGLSSSEQNWANLTTEERLASSRPPLFLDPPPQNGQKPPSRPSSSASKKQYV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Skin Hemangioma and Hemangioma Of Liver

Location

Expressed in multiple organs and tissues; including heart; uterus; ovary; and blood vessel endothelium

DOI ID

10.1172/jci116321; 10.1038/ng1285; 10.1038/nature04727; 10.1101/gr.2596504; 10.1093/carcin/17.8.1761; 10.1046/j.1365-2796.1999.00564.x; 10.1002/(sici)1097-0215(20000401)86:1<67::aid-ijc10>3.0.co;2-1

RefSeq

NP_002051.2; XP_005270807.1; XP_016856532.1